Multiple Regression Moderation

12/15/21, 5:09 PM Socioeconomic status, financial stress, and glucocorticoid resistance among youth with asthma: Testing the moderation effects o…

https://www.sciencedirect.com/science/article/abs/pii/S0889159121001951?via%3Dihub 1/8

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Brain, Behavior, and Immunity Volume 96, August 2021, Pages 92-99

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Socioeconomic status, financial stress, and glucocorticoid resistance among youth with asthma: Testing the moderation effects of maternal involvement and warmth

Yanping Jiang, Allison K. Farrell, Erin T. Tobin, Henriette E. Mair-Meijers, Derek E. Wildman, Francesca Luca, Richard B. Slatcher, Samuele Zilioli

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https://doi.org/10.1016/j.bbi.2021.05.014

Abstract

Objectives

Children who grow up in more socioeconomically disadvantaged homes experience greater levels of inflammation and worse asthma symptoms than children from more advantaged families. However, recent evidence suggests that certain family-level factors can mitigate health disparities associated with socioeconomic status (SES).

In a sample of youth with asthma, we investigated the potential buffering effects of maternal involvement and warmth on SES disparities in asthma-related immune responses, assessed via glucocorticoid resistance (GR) of immune cells.

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12/15/21, 5:09 PM Socioeconomic status, financial stress, and glucocorticoid resistance among youth with asthma: Testing the moderation effects o…

https://www.sciencedirect.com/science/article/abs/pii/S0889159121001951?via%3Dihub 2/8

Methods

One hundred and forty-three youth (10–16 years of age) with asthma completed measures of maternal involvement and warmth, and their primary caregivers reported their levels of education, income, and financial stress.

Peripheral blood mononuclear cells from youth’s blood were isolated, cultured, and assayed to determine mitogen-stimulated (PMA/INO + Ethno) and mitogen/hydrocortisone-stimulated (PMA/INO + Cort) levels of two Th-2 cytokines (i.e., interleukin-5, interleukin-13) and one Th-1 cytokine (i.e., interferon-γ).

GR was calculated by subtracting log-transformed cytokine concentration in the PMA/INO + Ethno samples from log-transformed cytokine concentration in the PMA/INO + Cort samples.