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According to Marken and Carey (2015), psychotherapy also defined as talk therapy is means of supporting individuals suffering from an extensive range of mental health disorders and emotional complications. An exponentially increasing interest in incorporating psychotherapy with the neuroscience has developed influentially during the past 10 years (Marken & Carey, 2015). The understanding of biological foundations of complicated behaviors and human brain along with their maladaptive reactions and the way psychotherapy support psychopathologies declared psychotherapy as a biological treatment (Plakun, 2015). Psychotherapy is regarded as brain therapy that allows individuals to re-elaborate their sense of self through new experiences that entails cognitive, emotional, and internal regulation processing (Marken & Carey, 2015). Similar to all other forms of learning and experience processing, psychotherapy can cause long-term detectable physical modifications in the brain (Marken & Carey, 2015). According to Straub, et al., (2015), psychotherapy has been identified to change activity levels in the prefrontal cortex. The individuals suffering from depression tend to have a high levels of activity in the prefrontal cortex and the individuals who attended interpersonal therapy were identified to have a decline in their prefrontal cortex activity (Straub, et al., 2015).