Quantitative genetic analysis

Quantitative genetic analysis

Rapid Critical Appraisal (RCA) Comparisons: Quantitative

Name Deneshia Dawkins

QUANTITATIVE

APA Reference

Contreras, J., Hare, E., Chavarria, G., Raventos, H. (2017) Quantitative genetic analysis of anxiety trait in bipolar disorder.

Johnson, C., Follmer, R., Oguz, I., Warren, L., Christensen, G., Fiedorowicz, J., Magnotta, V., Wemmie, J. (2015) Brain abnormalities in bipolar disorder detected by quantitative T1p mapping. Macmillan Publishers Limited.

Purpose and or problem

Does genetics and biopsychosocial problems cause patients with Bipolar disorder to display anxiety?

Does abnormal metabolism in the brain in Bipolar patients limited to one particular area?

Relevance to Nursing

It is important for nurses to learn what triggers anxiety in patients, in order to assess and implement interventions.

This is important for nurses to understand the disease process that will facilitate teaching to patient and family members.

Setting

Other

Country: Central Valley of Costa Rico

Choose an item.

Country: Iowa

Sample

Size : 619

Type: 61 extended families and 51 unrelated healthy controls.

Randomized? Yes ☐ No ☒

Size : 30

Type: 15 with DSM-IV diagnosis of bipolar 1 and 25 normal controlled group with no known psychiatric history

Randomized? Yes ☐ No ☒

Hypothesis

Easy to find? Yes ☒ No ☐

What is it? Subclinical anxiety as a heritable trait genetically correlates wit.h Bipolar Disorder 1

Easy to find? Yes ☒ No ☐

What is it? T1p would be elevated in bipolar 1 disorder.

Independent variable (s)

Anxiety traits

T1 mapping

Dependent variable

Measurement of anxiety experienced over a lifetime

Brain Abnormalities

How is dependent variable measured? (Tools and/or Validity)

By using clinical information obtained from the Dagnostic interview for genetic Studies and using the STAI. The STAI is a self-rated instrument that measures anxiety

Variable measured using a 3 T siemens Tim Trio MRI system

Reliability statistics

Yes ☐ No ☐

If yes, which ones were reported? Click or tap here to enter text.

Yes ☒ No ☐

If yes, which ones were reported? Images were reported showing different sides of the brain.

Data analysis

Quantitative (Choose from drop down).

Descriptive: Choose an item.

Variate: Choose an item.

Correlational: Choose an item.

Inferential: Choose an item.

Other: experimental

Quantitative (Choose from drop down).

Descriptive: Choose an item.

Variate: Choose an item.

Correlational: Choose an item.

Inferential: Choose an item.

Other: experimental

Unusual events?

Yes ☐ No ☒

If yes, explain: Click or tap here to enter text.

Yes ☐ No ☒

If yes, explain: Click or tap here to enter text.

Sample attrition?

Yes ☐ No ☒

If yes, explain: Click or tap here to enter text.

Yes ☐ No ☒

If yes, explain: Click or tap here to enter text.

Findings (Results)

The research was a limited success. The researcher was unable to find significant difference in score of BP1 mood status.

Lithium having a normalized effect on the brain that helps to control BP.

Important to you in your practice?

Yes ☒ No ☐

Explain: The research is important aid in the understanding of BD and why patients with bipolar, react the way they do.

Yes ☒ No ☐

Explain: It helps nurses to understand how someone with bipolar brain works, leading to new evidence based practices.